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valproinska kiselina (za lečenje epilepsije i psihičkih oboljenja) može da uspori izlučivanje diazepama iz organizma i pojača njegovo dejstvo,pomaže u smanjivanju napetosti i razdražljivosti koje su posledica cerebralne spastičnosti (stanje izazvano bolešću ili povredom mozga ili kičmene moždine koje karakteriše slabost, nekoordinisani
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Primena leka Bensedin rastvor za injekciju u dozama preporučenim za pedijatrijske pacijente u indikacijama u nastavku teksta može odgovarati dozi propilenglikola koja prevazilazi Restrict izloženosti definisan od strane EMA.Rezultati retrospektivnih studija ukazuju da postoji povećan rizik od kongenitalnih malformacija kod novorođenčadi majki